Launching January 2022
NEJM Evidence. Evaluate the reasons. Understand the results. NEJM Evidence. Evaluate the reasons. Understand the results.
NEJM Evidence, a new monthly digital journal from NEJM Group, presents innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.

Aims and Scope

The volume of clinical research continues to grow, yet the standards to establish and validate claims, especially as related to clinical practice, have not followed suit. NEJM Evidence expands the corpus of published research with a focus on providing more context and critical evaluation of the methods and results to support clinical decision-making, but does so in a way that respects the time and commitment of the practitioner.

Journal Information

ISSN: 2766-5526

Medium: Digital-Only

Frequency: Monthly (12 issues/year) with continuous publication

NEJM Evidence seeks to advance clinical trial research and clinical practice by:
  • Publishing high-quality studies from the frontline of medical research
  • Encouraging the medical community to take new approaches to clinical trial design and execution that yield more powerful clinical evidence
  • Sparking debate and conversation around areas of medicine where clinical decisions are made without sufficient evidence
  • Challenging practicing physicians to engage in a more meaningful way with clinical evidence
The journal adheres to the same rigorous standards of peer review and publication quality expected from NEJM Group. We publish:
  • Original research reports, clinical trials, and other clinically grounded work (e.g., population epidemiology studies, first-in-man trials, and meta-analyses) that validate or challenge prior clinical findings
  • Standard reviews, systematic reviews, and other review types that contextualize research findings with the aim of accelerating clinical adoption of new evidence
  • Case studies and reviews of clinical trial methodology that enhance understanding of trial strengths and weaknesses
  • A journal club article review series and case presentations in morning report format
Unique content and features include:
  • Tomorrow’s Trial, a series of short pieces that highlight accepted practices lacking solid evidence and inviting clinician readers to propose clinical trials to fill those gaps
  • Patient Platform, in which patients who have been in a clinical trial or part of a research study share their thoughts on their experience
  • Trial by Fire, a podcast that features 5-minute discussions between a person associated with a published trial and a critic of the trial
  • Stats, STAT!, a brief animated video explaining a statistical concept based on a statistical review

Generation of Evidence

The process of generating evidence is a key area of focus for NEJM Evidence. We push readers to evaluate the reasoning behind the complex decisions that investigators make in trial design and execution and to assess the quality of evidence produced in trials. Our goal is to build a community that takes a sophisticated approach to evaluating evidence and assessing its impact on clinical decisions.

Statistical Methods

NEJM Evidence also guides readers toward a deeper understanding of the statistical methods used in trials. We provide concise, digestible explanations of these methods and how to interpret the resulting data. In addition, we introduce readers to emerging statistical methods and types of data that will play an increasingly prominent role in future trials.

Multidisciplinary Coverage

The journal publishes content relevant across all general medical disciplines with an emphasis on cardiology, oncology, and infectious diseases. Physician-scientists, general medicine clinicians, subspecialty physicians, and clinical trialists will all benefit from this publication.

Editorial Team

NEJM Evidence physician-editors are dedicated to advancing clinical medicine and working with clinicians on improving clinical trial studies.

editorial team member photo


Jeffrey M. Drazen, MD

Jeff joined the New England Journal of Medicine (NEJM) as Editor-in-Chief in 2000 and was appointed Editor-in-Chief, NEJM Group, in 2012, serving in both roles until 2019. He is now NEJM Group Editor and Editor-in-Chief of NEJM Evidence.

editorial team member photo

executive editor

Chana A. Sacks, MD, MPH

Chana joined NEJM as a 2014-2015 NEJM Editorial Fellow and has served as Editor of Images in Clinical Medicine since 2016. She is Co-Director of the Massachusetts General Hospital (MGH) Center for Gun Violence Prevention and a Clinician-Investigator in the MGH’s Division of General Internal Medicine and Mongan Institute, where she is also a Health Policy Researcher.

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deputy editor

C. Corey Hardin, MD, PhD

Corey joined NEJM as Reviews Editor in 2021. He is an Assistant Professor of Medicine at Harvard Medical School and a member of the joint Harvard-MIT Program in Health Sciences and Technology faculty.

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statistical editor

Sharon-Lise T. Normand, MSc, PhD

Sharon-Lise joined NEJM as a Statistical Editor in 2017. She is the S. James Adelstein Professor of Health Care Policy in the Department of Health Care Policy at Harvard Medical School and a Professor in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health.

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2020-2021 nejm editorial fellow

Siri Kadire, MD

Siri is an Editorial Fellow with NEJM. She holds a BA in medicine, health, and society from Vanderbilt University and an MD from the University of Tennessee. She completed her training in internal medicine at Indiana University and plans to pursue a fellowship in cardiovascular disease.

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editorial coordinator

Neil Galloway

Neil joined NEJM in 2012, working in both manuscript editing and editorial operations. In 2016, he became the Executive Assistant to Jeff Drazen. He holds a BA in strategic communications from The Ohio State University.


Editorial Office

860 Winter Street
Waltham, MA 02451-1413
Contact Us

Please address general editorial inquiries and correspondence to the editorial office:

Institutional Subscriptions

Online access is available for purchase at an institution-wide level. For more information, contact the NEJM Group institution sales team at